UA is led by Prof van der Linden where the core R&D activity of the Bio-Imaging Lab at the University of Antwerp is concentrated on high resolution in vivo Magnetic Resonance Imaging. Their work focuses on early detection and understanding of the mechanisms underlying neurodegeneration, neurodevelopmental and mood disorders including Parkinson's, Huntington's, AD, schizophrenia and depression. There is also the Expert Group Antwerp Molecular Imaging (EGAMI) which represents a service platform that integrates all imaging techniques and expertise present at the University of Antwerp. This is co-ordinated by Dr Pieter-Jan Guns.

 

General description The Bio-Imaging lab is part of the Expert Group Antwerp Molecular Imaging (EGAMI), which integrates the imaging techniques and expertise present at the University of Antwerp. This covers cellular (microscopy) up to the whole animal imaging (microMRI,-PET,-SPECT,-BLI,-CT and combinations thereof). The participating teams have access to all the imaging modalities.
Staff Expertise Prof Annemie van der Linden is currently Vice President of ESMI and Director of the Bio-Imaging Lab core facility of UA. She is a leading figure for in vivo imaging of small animals with 20 years experience mainly with brain but also other tissue imaging. Her work focuses on early detection and understanding of the mechanisms underlying neurodegeneration, neurodevelopmental and mood disorders including Parkinson's, Huntington's, AD, schizophrenia and depression. Dr Pieter-Jan-Guns is Research & Innovation Manager of EGAMI. His work aims to translate academic expertise in bio-medical imaging into applied tools to support R&D in pharmaceutical and biotech industry.
Key facilities and infrastructure The lab is fully equipped and staffed for in vivo non-invasive small animal imaging, housing two fully equipped 7T Pharmascans (Bruker BioSpin, Germany) and a 9.4T BioSpec horizontal bore Magnetic Resonance Imaging system (Bruker BioSpin, Germany). All come complete with physiological monitoring setups with acquisition and post-processing protocols for various MRI modalities. There is also an in vivo bio-luminescence and fluorescence camera (Biospace, France).
Previous involvement in Research Programmes

Historical EU projects:

  • 2007-2009 EU FP6 STREP ratstream: characterization of transgenic rat models for neurodegenerative and psychiatric diseases.

Historic European training networks:

  • 2005-2010 EU FP7 DiMi - Diagnostic Molecular Imaging
  • 2004-2009 FP6 EMIL - European Molecular Imaging Laboratories
Current Involvement in Research Programmes
  • 2008-2013 EU FP7: NAD - Nanoparticles for therapy and diagnosis of Alzheimer Disease
  • 2012-2017 EU FP7: InMind - Imaging of Neuroinflammation in Neurodegenerative Diseases
Publications
  • Delgado y Palacios R et al. Biol Psychiatry. 2011; Sep 1; 70(5):449-57. Van der Linden A et al. NMR Biomed. 2007; Aug; 20(5):522-45. Review. Jonckers E et al. PLoS One 2011; 6: e18876

News

Publications

Adamczak J. et al. (2015).
Poststroke angiogenesis, Con: Dark side of angiogenesis.
- DOI: 10.1161/STROKEAHA.114.007642
Keuters M. et al. (2015).
Transcranial direct current stiumulation promotes the mobility of engrafted NSCs in the rat brain.
- doi: 10.1002/nbm.3244
Škrášková K. et al. (2015)
Precise anatomical localization of accumulated lipids in Mfp2 deficient murine brains through automated registration of SIMS images to the Allen Brain Atlas.
- doi: 10.1007/s13361-015-1146-6
Tzoumas S. et al.
Spatiospectral denoising framework for multispectral optoacoustic imaging based on sparse signal representation.
- doi: 10.1118/1.4893530
Tzoumas S. et al.
Immune cell imaging using multi-spectral optoacoustic tomography.
- doi: 10.1364/OL.39.003523
Shah D et al. (2015)
Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI.
- doi: 10.1016/j.neuroimage.2015.01.009

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Funded by the EC

Project BRAINPATH is supported by, and carried out within the FP7 Programme IAPP, funded by the EC

 

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