PERC is led by Dr Chan. The company possesses enabling tools (optical imaging and gene reporter assays) to validate efficacy of drugs, cell therapy and image-guided surgery. The in vitro, in vivo and ex-vivo models thus form the basis of an important screening program, not only for PERC, but for many companies operating in the fields of skeletal biology, stroke (regenerative medicine), TBI and cardiovascular medicine for which these assays are also offered as fee-for-service. The expertise and methods offered to the consortium will be based around the spatiotemporal optical imaging using time domain (fluorescence lifetime) technology and the subsequent co-registration of these images with other (anatomical) imaging modalities.

 

General description Percuros has a product portfolio of cell-based assays and specialised equipment dedicated to optical imaging using spatiotemporal tracking of cells in vivo. The company possesses enabling tools (optical imaging and gene reporter assays) to validate efficacy of drugs, cell therapy and image-guided surgery. 
Staff Expertise Dr Alan Chan was co-founder, Vice President of Research and Chairman of the scientific advisory board of biotech company, PamGene from 2000 - 2005. In 2005, he founded Percuros where he still works in the lab to offer hands-on expertise in optical imaging of brain, tumour immunology, regenerative medicine and skeletal biology events. Dr. Karien de Rooij obtained her PhD in 1998 working on Huntingdon’s disease. In 2009, she moved to Percuros where she specialises in cell-based and in vivo optical imaging of the brain.
Key facilities and infrastructure The lab is fully equipped and staffed for in vivo non-invasive small animal imaging, cell-based assays and development of new in vivo models and gene reporter assays. Equipment includes ART Optix MX3 time domain imaging, Softscan clinical breast scanner based upon pathophysiological absorbance changes in haemoglobin, water and lipids, Cell-based and organ imaging, and Luciferase mutant constructs. The expertise and methods offered to the consortium will be based around the spatiotemporal optical imaging using time domain (fluorescence lifetime) technology and the subsequent co-registration of these images with other (anatomical) imaging modalities.
Previous involvement in Research Programmes
  • 2009 – 2011: FP7 ‘TALOS’ grant to investigate LRP5 / Wnt signaling with respect to the treatment of osteoporosis
Current Involvement in Research Programmes
  • 2009 – 2011: FP7 ‘TALOS’ grant to investigate LRP5 / Wnt signaling with respect to the treatment of osteoporosis
  • 2010 – 2014: IOP Photonics grant for the study of photodynamic therapy and upconversion nanoparticles in the treatment of cancer
  • 2010 – 2013: BMM OA Control – Imaging of biomaterials as treatment for osteoarthritis 
  • 2010 – 2013: Near Infra-Red Fluorescent Detection of Tumour Tissue and Lymphatic Networks Using Nanoprobes
Publications
  • Xie BW et al. PLoS One. 2012;7(2):e31875. Epub 2012 Feb 13
  • Chan AB, et al. Curr Cardiovasc Imaging Rep. 2012: 5(1):11-18. Epub 2011 Nov 5
  • Kaijzel EL et al Circ Cardiovasc Imaging. 2010: 3(5):567-77. Epub 2010 Jun 30

News

Publications

Adamczak J. et al. (2015).
Poststroke angiogenesis, Con: Dark side of angiogenesis.
- DOI: 10.1161/STROKEAHA.114.007642
Keuters M. et al. (2015).
Transcranial direct current stiumulation promotes the mobility of engrafted NSCs in the rat brain.
- doi: 10.1002/nbm.3244
Škrášková K. et al. (2015)
Precise anatomical localization of accumulated lipids in Mfp2 deficient murine brains through automated registration of SIMS images to the Allen Brain Atlas.
- doi: 10.1007/s13361-015-1146-6
Tzoumas S. et al.
Spatiospectral denoising framework for multispectral optoacoustic imaging based on sparse signal representation.
- doi: 10.1118/1.4893530
Tzoumas S. et al.
Immune cell imaging using multi-spectral optoacoustic tomography.
- doi: 10.1364/OL.39.003523
Shah D et al. (2015)
Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI.
- doi: 10.1016/j.neuroimage.2015.01.009

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Funded by the EC

Project BRAINPATH is supported by, and carried out within the FP7 Programme IAPP, funded by the EC

 

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