LUMC is led by Prof. Lowik and Prof van den Maagedenberg. The group of Professor van den Maagdenberg (and including clinician Professor Ferrari) at LUMC constitutes one of the leading teams in the world for the study and unravelling of migraine pathophysiology. The facilities are state-of-art and in the context of being a medical research centre, this team can provide first-rate training and mentoring to ERs and ESRs. The group of Professor Lowik is one of the leading molecular imaging groups in the world as it specialises in translating preclinical optical imaging techniques towards the use of fluorescence-based probes in surgery.

 

General description LUMC is a long established medical institute with 7000 staff and focuses on top clinical and highly specialized care. This is backed up by top tier research groups including imaging and neurology for which it has world renowned status.
Staff Expertise The groups of Prof van den Maagdenberg and Prof Ferrari constitute one of the leading teams in the world for the study and unravelling of migraine pathophysiology. Professor Michel Ferrari is the migraine expert of the Netherlands and one of the six so-called ‘Headache Masters’ in the world. The group of Professor Lowik is one of the leading molecular imaging groups in the world as it specialises in translating preclinical optical imaging techniques towards the use of fluorescence-based probes in surgery. 
Key facilities and infrastructure The labs of the respective research groups are is fully equipped and staffed for in vivo non-invasive small animal imaging (Radiology) and brain analysis (Neurology and Human Genetics). The imaging labs include a clinical intra-operative camera system (Artemis), various preclinical optical systems and three MRI systems including an ultra- high magnetic field (17.6 Tesla) instrument. The brain analysis lab has a set up for stroke induction (MCAo) in mice and various electrophysiology setups.
Previous involvement in Research Programmes
  • 2000 EC FP5: Research Training Network; Neuronal Calcium channels in human disease
  • 2004 EC FP6: Lifesciences, Genomics & Biotechnology for Health
  • 2004 EC FP6: STREP; Migraine genes and neurobiological pathways (EUROHEAD) 
  • 2005 EC FP6: European network for research on Alternating Hemiplegia in Childhood for promoting SMEs integration
  • 2007 EC FP7: Diagnostic Molecular Imaging (DIMI)
  • 2008 EC FP7 European network for rare neurological diseases (nEUroped) 
  • 2008 EU FP7: Targeting LRP5 to increase bone formation in osteoporosis 
  • 2008 EU FP7: European Network for Cell Imaging and Tracking Expertise
Current Involvement in Research Programmes
  • 2011 – 2014: Cancer Vaccine Tracking. Funding a Post doc and bench fee for 3 years. Source: CTMM project. Acronym: CVT. 
  • 2011 – 2014: Image-Guided And / Or Targeted Photodynamic Therapy Using A Combination Of A New Photosensitiser With Upconverting Nanoparticles. 
  • 2010 – 2014: NMC project grant, Metabolomics in migraine patients and mice
  • 2010 – 2013: FP7-funded NIMBL grant “NIMBL—Nuclease Immune Mediated Brain and Lupus-like conditions
Publications
  • Chasman DI et al Nat. Genet. 2011; 43:695-8
  • Richards A et al. Nat. Genet. 2007; 39:1068-70
  • Freilinger T et al Nat. Genet. 2012; 44:777-82

News

Publications

Adamczak J. et al. (2015).
Poststroke angiogenesis, Con: Dark side of angiogenesis.
- DOI: 10.1161/STROKEAHA.114.007642
Keuters M. et al. (2015).
Transcranial direct current stiumulation promotes the mobility of engrafted NSCs in the rat brain.
- doi: 10.1002/nbm.3244
Škrášková K. et al. (2015)
Precise anatomical localization of accumulated lipids in Mfp2 deficient murine brains through automated registration of SIMS images to the Allen Brain Atlas.
- doi: 10.1007/s13361-015-1146-6
Tzoumas S. et al.
Spatiospectral denoising framework for multispectral optoacoustic imaging based on sparse signal representation.
- doi: 10.1118/1.4893530
Tzoumas S. et al.
Immune cell imaging using multi-spectral optoacoustic tomography.
- doi: 10.1364/OL.39.003523
Shah D et al. (2015)
Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI.
- doi: 10.1016/j.neuroimage.2015.01.009

Read More

Funded by the EC

Project BRAINPATH is supported by, and carried out within the FP7 Programme IAPP, funded by the EC

 

Supported by

Log--Marie-Cuire-Actions-120px

 

Contact Us

 
+31 (0)487-532641
 
 
PO Box 217
7500 AE Enschede
The Netherlands
 
 
This email address is being protected from spambots. You need JavaScript enabled to view it.