AMOLF is led by Prof Heeren. The Heeren group is one of the world leaders in high resolution molecular imaging of biological surfaces where AMOLF provides a unique, state-of-the-art infrastructure for atomic and molecular imaging of surfaces. It targets the development and application of state-of--art mass spectrometry based molecular imaging approaches. The application of molecular imaging using mass spectrometry in molecular histology is one of the breakthrough technologies in modern biomedical research.
|General description||A specialist biomolecular imaging group which provides a unique, state-of-the-art infrastructure for atomic and molecular imaging of surfaces.|
|Staff Expertise||Prof Ron Heeren‘s group is currently one of the world leaders in high resolution molecular imaging of biological surfaces. This leading position has been realized through a concerted research effort on three topics (a) the fundamental physics of desorption and ionization of large biomolecules (b) the development of innovative instruments and methods for the generation of ultrahigh resolution molecular images and (c) the development and application of mass spectrometry based molecular imaging to molecular histology for nanomedicine and biomedical research.|
|Key facilities and infrastructure||
The mass spectrometry based molecular tissue imaging facility at AMOLF is equipped with a 9.4T MALDI/ESI Fourier Transform Ion Cyclotron Resonance imaging mass spectrometer, a 7T LTQ-FTICR system for atmospheric ionisation and imaging, a Bruker Ultraflex III ToF/ToF MALDI molecular imager, a Physical Electronics TRIFT II high resolution secondary ion mass spectrometry (SIMS) ToF-MS system, the TRIFT II based AMOLF mass microscope for direct ion imaging with MALDI and SIMS and a Waters MALDI Synapt HDMS system for conformational molecular imaging.
|Previous involvement in Research Programmes||
|Current Involvement in Research Programmes||