ParticipantsCity, CountryLegal Entity NameDepartment/Division/ LaboratoryScientist-in-Charge
1- PERC Enschede, NL Percuros BV R&D Alan Chan
2- icoMetrix Leuven, Belgium icoMetrix NV R&D Dirk Smeets
3- Medres Cologne, Germany Medres-Medical Research GmbH R&D Stefan Wecker
4- LUMC Leiden, NL Academisch Ziekenhuis Leiden – Leids Universitair Medisch Centrum Radiology, Neurology and Human Genetics Clemens Lowik and Arn van den Maagdenburg
5- AMOLF Amsterdam, NL Institute for Atomic and Mol. Physics Biomolecular Imaging Mass Spectrometry Group (BIMS) Ron Heeren
6- UA Antwerp, Belgium Universiteit Antwerpen Bio-Imaging Lab and EGAMI Annemie Van Der Linden
7- MPI Cologne, Germany Max-Planck-Institut für neurologische Forschung In Vivo NMR Group Mathias Hoehn
8- TUM München, Germany Technische Universität München Chair for Biological Imaging, TU Munich Vasilis Ntziachristos

UNIVERSITEIT ANTWERPEN (UA)

is led by Prof van der Linden where the core R&D activity of the Bio-Imaging Lab at the University of Antwerp is concentrated on high resolution in vivo Magnetic Resonance Imaging. Their work focuses on early detection and understanding of the mechanisms underlying neurodegeneration, neurodevelopmental and mood disorders including Parkinson's, Huntington's, AD, schizophrenia and depression. There is also the Expert Group Antwerp Molecular Imaging (EGAMI) which represents a service platform that integrates all imaging techniques and expertise present at the University of Antwerp. This is co-ordinated by Dr Pieter-Jan Guns.

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TECHNISCHE UNIVERSITAET MUENCHEN (TUM)

is led by Prof Ntziachristos, Director of the Institute for Biological and Medical Imaging (IBMI) of the Helmholtz Center Munich and the Technical University of Munich.  Based at the Medical School and Hospital of the Technical University of Munich, the medical imaging laboratory focuses on the propagation of new preclinical and clinical imaging technologies into healthcare. It has a world leading position in the use of fluorescence imaging methods for intra-operative and endoscopic imaging including miniaturized imaging scopes for intravascular imaging. This includes state-of-art hybrid fluorescence and X-ray tomography systems. 

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ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM (LUMC)

is led by Prof. Lowik and Prof van den Maagedenberg. The group of Professor van den Maagdenberg (and including clinician Professor Ferrari) at LUMC constitutes one of the leading teams in the world for the study and unravelling of migraine pathophysiology. The facilities are state-of-art and in the context of being a medical research centre, this team can provide first-rate training and mentoring to ERs and ESRs. The group of Professor Lowik is one of the leading molecular imaging groups in the world as it specialises in translating preclinical optical imaging techniques towards the use of fluorescence-based probes in surgery.

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ICOMETRIX NV (icoMetrix)

is led by Dr Smeets. The Company provide researchers, medical companies and clinicians access to state-of-the art quantitative image analysis methods by performing the analysis for them. The images are sent over the internet to the icoMetrix servers, analysed by experts, and the results are sent back, either as a report or for interactive review by the customer. Their analysis pipeline builds upon a fertile ground of quantitative image processing algorithms. IcoMetrix will use their library and experience in quantitative image processing algorithms and computing facilities to carry out their objectives for the consortium.

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PERCUROS BV (PERC)

is led by Dr Chan. The company possesses enabling tools (optical imaging and gene reporter assays) to validate efficacy of drugs, cell therapy and image-guided surgery. The in vitro, in vivo and ex-vivo models thus form the basis of an important screening program, not only for PERC, but for many companies operating in the fields of skeletal biology, stroke (regenerative medicine), TBI and cardiovascular medicine for which these assays are also offered as fee-for-service. The expertise and methods offered to the consortium will be based around the spatiotemporal optical imaging using time domain (fluorescence lifetime) technology and the subsequent co-registration of these images with other (anatomical) imaging modalities.

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INSTITUTE FOR ATOMIC AND MOLECULAR PHYSICS (AMOLF)

is led by Prof Heeren. The Heeren group is one of the world leaders in high resolution molecular imaging of biological surfaces where AMOLF provides a unique, state-of-the-art infrastructure for atomic and molecular imaging of surfaces. It targets the development and application of state-of--art mass spectrometry based molecular imaging approaches. The application of molecular imaging using mass spectrometry in molecular histology is one of the breakthrough technologies in modern biomedical research.

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MAX-PLANCK-INSTITUT FÜR NEUROLOGISCHE FORSCHUNG KÖLN (MPI)

is led by Prof Hoehn where his research interest focuses on regeneration of cerebral lesions, in particular stroke. He is Head of the in vivo NMR group at the MPI where his goal is to stimulate regeneration through implantation of embryonic stem cells and thereby explore their therapeutic potential. MPI has expertise in developing preclinical stroke models observed under MRI and optical imaging. It has an internationally standing for imaging of stem cell based regeneration processes. 

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MEDRES-MEDICAL RESEARCH GMBH (Medres)

is led by Dr Wecker. Medres Medical Research GmbH has built up specialisation towards developing tools related to imaging devices. Their expertise has been influential in helping the MPI to cement its worldwide leading position for highly resolved in vivo MRI for investigation of cerebral lesions and for molecular MR imaging for cell tracking in the brain. The company started with hardware development for experimental high resolution MRI at field strength from 4,7 – 11,7 T (especially the cryodetector) and then expanded the spectrum of modalities to optical imaging, PET and CT.

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News

Publications

Adamczak J. et al. (2015).
Poststroke angiogenesis, Con: Dark side of angiogenesis.
- DOI: 10.1161/STROKEAHA.114.007642
Keuters M. et al. (2015).
Transcranial direct current stiumulation promotes the mobility of engrafted NSCs in the rat brain.
- doi: 10.1002/nbm.3244
Škrášková K. et al. (2015)
Precise anatomical localization of accumulated lipids in Mfp2 deficient murine brains through automated registration of SIMS images to the Allen Brain Atlas.
- doi: 10.1007/s13361-015-1146-6
Tzoumas S. et al.
Spatiospectral denoising framework for multispectral optoacoustic imaging based on sparse signal representation.
- doi: 10.1118/1.4893530
Tzoumas S. et al.
Immune cell imaging using multi-spectral optoacoustic tomography.
- doi: 10.1364/OL.39.003523
Shah D et al. (2015)
Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI.
- doi: 10.1016/j.neuroimage.2015.01.009

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Funded by the EC

Project BRAINPATH is supported by, and carried out within the FP7 Programme IAPP, funded by the EC

 

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